BEIJING - Nanozymes, nanomaterials with intrinsic enzyme-like activities, have been widely used in cancer diagnosis in recent years, but controlling their performance in treating a target tumor cell remains a challenge.A research team, jointly led by Yan Xiyun from the Institute of Biophysics under the Chinese Academy of Sciences and Gao Lizeng from Yangzhou University, has for the first time developed a strategy to coordinate nanozymes to target tumor cells and selectively kill tumors. Their findings were published in Nature Communications last week.During tumor growth and development, elevated levels of hydrogen peroxide (H2O2) are often exhibited in solid tumors, which render tumor cells more resistant to therapeutic treatment.This situation reduces the effect of chemotherapy. If the accumulated H2O2 can be combined with oxygen to be converted into a toxic reactive oxygen species, this may enable more effective means of tumor therapy, according to Yan.Previously natural enzymes were used, however, they were less sensitive and not as stable, so enzyme mimics or artificial enzymes were developed, but the efficiency of enzyme mimics was often insufficient.Therefore, the team has developed a nanozyme which has shown excellent bio-compatibility.To optimize its performance for tumor therapy, scientists used ferritin, an intracellular protein found in most human tissue, to modify the surface of the nanozymes to enable them to target tumors.Tests demonstrated that ferritin-modified nanozymes suppressed tumors in animal models, and proved the feasibility of using nanozymes for tumor therapy."If modified, nanozymes can function as Trojan horses, transporting cell-destroying compounds into tumor cells," said Yan.Nanozymes can be fine-tuned via size, dosage, and surface modification. In addition, they have multiple functions, high stability, and are easy to scale up at a low cost, according to the study."We hope this nanozyme-based tumor therapy can enable new strategies for cancer treatment," Yan said. silicone medical alert bracelet diabetescustom silicon wristbandsmedical id silicone wristbandsdual layer wristbandsanimal bracelets rubber bands
ZHAOJUE, Sichuan -- President Xi Jinping pledged to exorcise the evils of ignorance, backwardness and poverty during his visit to ethnic villages in Sichuan province in Southwest China.While visiting homes of impoverished villagers of the Yi ethnic group who live deep in the Daliang Mountains of Zhaojue county, Xi, also general secretary of the Communist Party of China Central Committee, called for efforts to win the battle against poverty.He stressed that not a single ethnic group, family or individual should be left behind in the building of a moderately prosperous society in all respects in China, asking local officials to make unremitting and down-to-earth efforts in poverty alleviation.A Yi ethnic villager told Xi that she used to think that she was infested by some evils when she was ill in the past until she was told by village officials that the evils were just bacteria incurred by unsanitary lifestyle.Evils did exist in the past. They were the evils of ignorance, backwardness and poverty, Xi said. Once the people begin to lead a more civilized, healthier and better-off life, the evils are exorcised.Would you like to sing? Xi asked a 10-year-old girl after learning that she was fond of singing.Yes, the girl replied and sang. Xi applauded and praised her good singing.Before leaving the county, Xi, wearing Yi ethnic apparel, shook hands and said goodbye to the villagers.In their ethnic language, the villagers expressed their thanks, New Year greetings and best wishes to Xi.
